0:00 - 3:58 - Intro
- How diet can radically reduce mucsular pain by reducing Inflammation
- Looking at Saturated Fatty Acids (SFA’s) and how thry impact inflammation, Fascia & Pain
- Diet is the place to start for Pain
- Diet can radically reduce Pain within 2 weeks.
- What we are going to cover in the Podcast.
3:59 - 8:58 - The Inspiration
- Nieks Bear-Hunting Trip as the Inspiration for this Podcast
- Levaraging the Immunecentric Framework
- Niek’s Back Muscles were so tight that breathing was filtered down to a wheeze in the AM.
- Niek had 250g of Fatty Acids per day, lots of Free Fatty Acids (FFA) in serum
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8:59 - 13:33 - Immunity, Fascia and Your Fat Tissue
- This episode will be broken down —> We are going to look at pathways activated by high FFA in the diet, how we can reverse engineer it
- Fat (the tissue) is a vector for Inflammation
- Superficial Fascia and Subcutaneus Fascia are next-door neighbors
- Preadipocytes (Progenitors) can become Pro-Inflammatory (M1) Immune Cells under imbalanced conditions.
- An Immune Cell is a Sentinal; In a nutshell, Tissue Cells follow the behaviour of Immune Cells.
- House on Fire Analogy, How Inflammation in Fat immediately impacts Your Fascia.
13:34 - 17:28 - Too many FFA’s activate Ceramides which Activates Inflammation
- Keto Diets are supposed to be healthy, why is there a problem?
- Too much saturated Fatty Acids create more FFA’s in the serum
- Ceramide’s get produced; ceramides are a bioactive lipid (fat) that can act as a signalling molecule.
- Ceramide’s will target Fat Cells
- Ceramide’s have a section of their structure that is the same as LPS (Pro-Inflammatory Bacterial Fragments)
- Ceramides activate Immune Cells making them Pro-Inflammatory.
- Ceramides Bind TLR4 on Macrophages, activating Pro-Inflammatory Response
17:29 - 20:53- Excess FFA’s creates Friendly Fire on Tissue Cells by Inflammatory Activation
- Paper that explains Ceramides will increase Pro-Inflammatory markers, this is concomitant with Fibrosis.
- Excess FFA’s in serum are detected by IRE1a (Inositol Requiring Enzyme Type 1), IRE1 ultimate switch for entire Immune Respnse
- B & T Cells get activted
- Flips Mcrophages to M1
- Inflammasome —> Robot Godzilla gets activated
- IRE1a induces friendly -fire on Tissue via Immune System.
20:53 - 21:06 - Excessive FFA’s Review
- Too many FFA’s in the Blood create Endothelium (Vasculature) Dysfunction, Blood turns on Fire.
- FFA’s Inflammatory Cascade Review
21:07 - 25:37 - How & When MCT’s can be problematic
- MCT’s are researched to be anti-inflammatory, so whats going on?
- Long-term with MCT’s and over-Indulgence.
- C6, C8, C10 can very quickly be transported into the serum very quickly.
- Serum can get loaded with MCT’s very quickly.
- Too many MCT’s disrupt B-oxidation in Mitochondria.
- Excess MCT’s end up staying longer into the serum
- Contributes to too many FFA’s inducing pro-inflammatory signalling as mentioned above.
25:37 - 29:36 - How MCT’s can drive auto-immune issues
- The problems with researching effects of MCT’s
- Autoimmune (MS & encephalytis) has more C6 circulating in the serum.
- C8 and C10 seem to skew the ratio’s of Th1 : Th17 Cells towards excess Th17 Cells
- Excess Th17 = Autoimmune Issues (MS, Lupus, etc.)
- MCT’s can unravel the short-term effects of SCFA
- SCFA keep Th1 : Th17 Cell populations balanced, too many MCT’s prevent this.
29:37 - 33:14 - How MCT’s and Saturated Fats can be problematic for the Gut Biome long-term
- This explains how Keto, WAP, or Carnivore diets can create some problematic systemic inflammatory issues.
- Fat will favor bacteria that exist within the lumen
- Outcompete Commensals
- Commensals keep Mucus layer production high, promote tight junction gene expression, tune T-Helper (Th) Cell Population
- A sincere Inflammatoty Disaster, (LPS + Ceramides + Feeding Lumen Bacteria) —> Serious inflammatory probems.
- A High Fat Diet will create excessive ROS production and damage colonocytes.
- Diet has so much power over Inflammation
- Inflammation tightly linked to Fat Tissue, which has a tight relationship with Fascia.
33:15 - 36:23 - Niek’s Use Case
- Too many Long Chain Fatty Acids (LCFA’s)
- Too much FFA in the serum
- Too little Energy Expenditure
- Created Beautiful Breeding Ground for HIF-1 (Pro-inflammatory Protein) to blow inflammation through the roof
- Drives Myofibroblast populations up, creates fascial contracture
- Extreme “Muscle”/Fascial Tension
36:24 - 40:43 - Solution Sets
- Prevention for short Term = easiest, stick with MCTs for short-term and remove the saturated Long Chain Fatty Acids (LCFA’s)
- Long-term Keto, WAP, or Carnivore diets Mitigation
- Ideal situation —> Use cyclically, when off use Resistant starch or Immunecentric (IC)Approach
- Niek used the IC Approach to heal himself, cut his symptoms in half by each day.
- The IC Approach has the potential to completely shift Your inflammation in 1-2 weeks.
- How IC Approach works with the Immune System.
- If You have lots of Pain —> Start with Diet
40:44 - 43:23 - Keto Diets have massive benefits and how to use them.
- Should be used cyclically with functional foods
- Use cases where keto diets are beneficial; increasing metabolic flexibiliy, inducing fat-burning, activating autophagy pathways, etc.
- Its not a Way of Eating for Life, strategically it’s fantastic.
RESOURCES
- Ben Greenfields Pemmican Recipe
- Increased FFA increase Ceramide Prod.
- The Role of Ceramides in Insulin Resistance
- The Role of Fatty Acids in Ceramide Pathways and Their Influence on Hypothalamic Regulation of Energy Balance: A Systematic Review
- Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
- Bifido driven down by C10 Paper
- 2019 Frontiers of Endocrinology Paper- Ceramides increase M1
- IRE1a Papers
- IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases
- The unfolded protein response in immunity and inflammation
- Immunecentric Approach (Veep)
- Research Papers
- Short- and medium-chain fatty acids in energy metabolism: the cellular perspective
- Medium Chain Triglyceride (MCT) Oil Affects the Immunophenotype via Reprogramming of Mitochondrial Respiration in Murine Macrophages
- Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis
- Role of free fatty acids in endothelial dysfunction
- Medium Chain Triglyceride Oil: An Intended Placebo with Unexpected Adverse Effects
- Hyperlipidemias and Obesity
- Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload
- Effect of plasma free fatty acid supply on the rate of ceramide synthesis in different muscle types in the rat
- Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease
- Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy
