0:00 - 4:31 - Intro
- Fibroblast-Immunity Quick Review
- The importance of Oxygen to Your cells.
- How Oxygen (O2) works in the Body; it acts on a Spectrum.
- External Environment —> Lungs —> Blood System than the order reverses.
- Ischemic Tissue (No blood Flow) = No O2 (The interface with Fascia.
- What we will be covering in this Podcast.
4:32 - 7:46 - Gut-Fascia Axis and Intro to the importance of the Lungs
- Cliffnotes on Immune System, the role of Fibroblasts and the Gut.
- Fibroblasts are located where there’s a lot of moving parts.
- New York Exchange Analogy
- Besides the Gut, the Lungs is another place of High traffic.
- How we handle the exchange between external & internal environment determines how healthy we are.
7:47 - 11:09 - Mechanism for how Immunity is driven in the Lungs
- Mechanism for how the Gut interfaces with the Immune System Review
- Same Players in Lungs; Wall, Bacteria, Immune System
- Key difference: Resident Population of Bacteria in the Gut; Lungs, the Immune System & Bacteria live on the same side of the wall.
- Anatomy of the Lungs; split in the Road and Grapes Analogy
11:10 - 14:31 - Whats happening with the cells that live in Your Alveoli
- Do it Now: Cow-hitch Handshake Analogy
- Lung Bacteria are visitors, not residents.
- What a Healthy Lung-Immune Mechanism looks like.
- There is a Fibroblast-Macrophage Crosstalk
- What an unhealthy situation looks like.
14:32 - 18:55 - Whats happening with the cells that live in Your Alveoli in anUnhealthy situation
- Unwanted guests Analogy
- Bacterial Diversity drops because theres pathogenic dominance.
- Alveolar Macrophages are designed to die-off.
- Plan B = Interstitial Macrophages —> sensitized to Anti-Inflammatory (M2) type
- The consequences of “Excessive Bacterial Burden”
- Interstitial Macrophages now live in alveoli, theysecrete TGF-b; communicates to Fibroblasts to activate and multiply.
- Consequences of Fibroblast Activation
- How the problem becomes exacberated Fibroblast to Myofibrblast Transition (FMT); Epithelial to Mesenchymal Transition (EMT).
- Ratchet Analogy of Myofibroblasts
- Bacterial Burden + slowing of Oxygen transfer = Problem
18:56 - 21:25 - What happens when the Inflammatory Response becomes chronic and how it affects Your Fascia
- Interstitial Macrophages stay in the alveoli; sensitized to activate the Fibroblasts, lowering the Oxygen transfer into the serum
- How this mechanism actually relates to You.
- No O2 = HIF-1
- HIF-1 allows for continual metabolic activity.
- Imbalanced Immunoty in Lungs = less O2 reaching tissue cells = more HIF-1 = more FMT (activated Fibroblast / Myofibroblasts)
- Net is Fascial Disease
21:26 - 23:22 - How COPD works and impacs Your Fascia
- The Body tries to breath harder to compensate for the tickened wall of Fibroblasts.
- Diaphragm adaptations
- Fatigued Diaphragm impacts the ribcage & Spine
- Zero O2 + Fighting Gravity + Circulating HIF-1 = complete disadvantage
23:23 - 28:21 - How to support Healthy Lung Activity from a Fascial Perspective
- The role of IL-17a.
- Synergizes with IL-33 and IL-13; creates a triage
- When Fibroblasts release these cytokines, turns Macrophages into M2 type (anti-inflammatory . pro-fibrotic)
- Niek speaks to this through his own experience.
- Niek shares his severe allergy story; didn’t sleep for more than10 hours over 2 weeks.
- Niek used Peppermint essential oil; anecdotally and hints in the research that these can block the pro-fibrotic cytokine triage.
28:22 - 31:54 - Targetting the Oral Microbiome to optimize Lung Function
- Niek also targetted Oral Microbiome.
- How Oral commensals support Immune function in the alveolus.
- What happens if Oral Commensals become unbalanced.
- Niek inoculate nose & throat with Streptococcus salivarius K12.
- Endemic role of S. salivarius K12 and how it impacts the lungs.
- Foods that feed S. salviarius are Inulin, fermented foods (& raw greens (waxy cuticle)
- Niek’s population of S. salivarius was so gret he thought he had cavities
31:55 - 34:59 - The Gut-Immune Axis can nt be overstated and close-out
- Review of how th Gut is connected to the Lungs vis the Immune System.
- a dysfunctional Gut creates a hyper-responsive lung environment.
- Start with Gut then go to the Mouth to target the Lungs.
RESOURCES
Research Papers
- Sensitivity of alveolar macrophages to substrate mechanical and adhesive properties
- Physical and mechanical regulation of macrophage phenotype and function
- Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
- Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms
- A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity
- Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?
Extra Prebiotic / Probiotic:
Streptococcus Salivarius M18 also works well (no link)
Sinusitis Experiment with L. Sakei B-2 - Video
